preparation, distribution, stability and tumor imaging properties of [<sup>62</sup>zn] bleomycin complex in normal and tumor-bearing mice
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abstract
backgrounds: bleomycin (blm) has been labeled with radioisotopes and widely used in therapy and diagnosis. in this study blm was labeled with [62zn] zinc chloride for oncologic pet studies. materials and methods: the complex was obtained at the ph=2 in normal saline at 90 ° c in 60 min. radio-tlc showed an overall radiochemical yield of 95-97% (radiochemical purity > 97%). stability of complex was checked in vitro in mice and human plasma/urine. results: preliminary in vivo studies performed to determine complex stability and distribution of [62zn] blm in normal and fibrosarcoma-bearing mice. [62zn] blm accumulated significantly in induced fibrosarcoma tumors in mice according to bio-distribution/imaging studies. conclusion: [62zn] blm can be used in pet oncology studies due to its suitable physico-chemical properties as a diagnostic complex in vitro and in vivo. further studies should be performed for evaluation of the complex behavior in higher animals. iran . j. radiat. res., 2003 1(1): 37 - 44.
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Journal title:
iranian journal of radiation researchجلد ۱، شماره ۱، صفحات ۳۷-۴۴
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